Fold change of mRNA expression of genes involved in epidermal barrier homeostasis and chemotaxis in murine skin after two weeks of topical treatment with retinoid receptor-specific agonists or antagonists.

1BMS753; 2BMS961; 3all-trans retinoic acid; 4LG268; 5BMS614; 6UVI2041; 7BMS493; 8UVI3003; 9gene also relevant as retinoid target gene; UDL, under detection limit.
Fold change data are expressed as mean ± SEM (n≥5) and were determined in skin specimens of topically treated mice by qRT-PCR. Statistical significance (p) was tested using one-way ANOVA followed by Dunnett’s post test. *p<0.05, #p<0.01, §p<0.001, versus control (acetone).