Hsd11b1

Enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity. Acts upstream of or within lung development. Predicted to be located in apical part of cell and nuclear membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study cortisone reductase deficiency 2. Human ortholog(s) of this gene implicated in cortisone reductase deficiency (multiple); hypertension (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]

激活11-β-羟基类固醇脱氢酶（NADP+）活性。该酶在肺发育的上游或内部发挥作用。预测其位于细胞顶端的细胞膜和核膜。预测其在内质网膜上具有活性。表达于多个结构中，包括消化系统；心血管系统；泌尿生殖系统；神经系统；以及感觉器官。用于研究皮质醇还原酶缺乏症2。该基因的人类同源基因与皮质醇还原酶缺乏症（多种）、高血压（多种）、肥胖症以及2型糖尿病有关。与人类HSD11B1（羟基类固醇11-β脱氢酶1）同源。[由基因组资源联盟提供，2024年11月]