The effect of hsa-miR-200c-3p/ZEB1 loop in the epithelial-mesenchymal transition of ovarian cancer

Ovarian cancer (OC) is the diagnosis of disease at advanced stages with distant metastasis described as the transition of cells from epithelial to mesenchymal phenotype (EMT).The expression of hsa-miR-200c-3p was analyzed on the ovarian tissues obtained from healthy individuals (n=15), and advanced epithelial OC (EOC) patients (n=15). ZEB1 is one of the target genes of hsa-miR-200c-3p and was determined by in-silico methods. The expression of ZEB1 was analyzed in both groups.The expression of hsa-miR-200c-3p was significantly increased in OC patients (p <0.05). ZEB1 expression level decreased significantly (p <0.05) in EOC group. The correlation analysis indicated a strong negative correlation between hsa-miR-200c-3p and the ZEB1 gene (r=-0,75; p<0,00).