Likelihood ratio test between the neighbor-dependent and hybrid models of metabolic evolution.

The maximum likelihood estimates (MLEs) of the parameter values (: insertion rate, : deletion rate and : neighbor dependence probability), maximum log-likelihoods, likelihood (LH) ratios, and the -values for different pathway maps in P. fluorescens Pf0-1 used in this analysis. The MLEs were obtained using the Gibbs sampler described by Mithani et al.[9] by evolving the networks from P. fluorescens Pf-5 to P. fluorescens Pf0-1. The equilibrium probability of a network was used as the likelihood of observing the network. The low -values for all the pathway maps suggest a better fit for the hybrid model compared to the neighbor-dependent model.