Chrd

Enables BMP binding activity; heparin binding activity; and proteoglycan binding activity. Involved in several processes, including cell surface receptor signaling pathway; circulatory system development; and modulation of chemical synaptic transmission. Acts upstream of or within several processes, including gastrulation; negative regulation of osteoblast differentiation; and osteoblast differentiation. Located in extracellular space. Is active in cell surface and extracellular region. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and skeletal system. Used to study DiGeorge syndrome and velocardiofacial syndrome. Orthologous to human CHRD (chordin). [provided by Alliance of Genome Resources, Nov 2024]

该数据集包含 BMP 绑定活性、肝素结合活性和蛋白聚糖结合活性；参与多种过程，包括细胞表面受体信号通路、循环系统发育以及化学突触传递的调节。在多个过程中发挥上游作用或位于其中，例如胚胎形成、成骨细胞分化的负调控以及成骨细胞分化。位于细胞外空间，活性存在于细胞表面和细胞外区域。在多个结构中表达，包括消化系统、鳃弓、中枢神经系统、泌尿生殖系统和骨骼系统。用于研究迪乔治综合征和快速心面综合征。与人类 CHRD（chordin）同源。[由基因组资源联盟提供，2024年11月]