Supporting data for "Population-level allelic dispersion modelling by maelstRom yields genome-wide maps of allele-specific dysregulation during early carcinogenesis."

This project introduces maelstRom, a software package for the modelling and statistical testing of Allelic Dispersion (AD). This AD highlights consistent differences in the expression between two alleles of a gene that is, unlike cis-eQTLs, independent of normal genetic variation. Such differences can, for example, arise from prevalent copy number alterations or epimutations occurring in the original cancer cell, which are mitotically expanded during cancer growth, making increased AD a marker for allele-specific dysregulation in early carcinogenesis. But outside of cancer, AD can indicate early (epi)genetic (dys)regulation in general biological phenomena. <em>maelstRom</em> is available as an open-source software package at github.com/Biobix/maelstRom.