Structure of human SHP2 in complex with compound 27

Structure of human SHP2 in complex with compound 27 Descriptor: Tyrosine-protein phosphatase non-receptor type 11, [3-(4-amino-4-methylpiperidin-1-yl)-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl]methanol Authors: Leonard, P.G, Cross, J. Deposit date: 2021-06-24 Release date: 2021-10-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Discovery of 6-[(3 S ,4 S )-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J.Med.Chem., 64, 2021