PAK1 phosphorylates myosin phosphatase

PAK1 phosphorylates the regulatory subunit MYPT1 (PPP1R12A) of the myosin phosphatase complex on threonine residue T696, thereby inhibiting the catalytic activity of the myosin phosphatase and indirectly increasing phosphorylation of the myosin regulatory light chain (MRLC) (Chu et al. 2013).

PAK1通过磷酸化肌球蛋白磷酸酶复合物的调节亚基MYPT1（PPP1R12A）上的苏氨酸残基T696，从而抑制肌球蛋白磷酸酶的催化活性，并间接增加肌球蛋白调节轻链（MRLC）的磷酸化水平（Chu 等人，2013年）。