Integrative genomic approach identifies glial transcriptomic dysregulation in the cortex of individuals with Alcohol Use Disorder

Nuclei were isolated from human postmartum brain frozen dorsolateral prefrontal cortex samples of AUD and control individuals. Libraries were prepared with 10X Genomics platform and sequenced using NovaSeq 6000. Post-filtering and site integration resulted in 464, 716 nuclei for downstream analysis. Single nucleus RNA sequencing (snRNA-seq) from dorsolateral prefrontal cortex of 36 AUD and 37 control individuals. UPDATE [Apr-25-2025] The numberings in the Sample titles and processed data file names were updated as per the GSE247416_old_new_numberings.xlsx file. The data did not change.