The Optimal Type and Dose of Exercise Interventions on VEGF Levels Across Different Populations A Network Meta-Analysis

Supplementary materials for "The Optimal Type and Dose of Exercise Interventions on VEGF Levels Across Different Populations: A Network Meta-Analysis"
This dataset contains supplementary materials supporting a systematic review and network meta-analysis examining the effects of different exercise interventions on vascular endothelial growth factor (VEGF) levels across healthy, obese, and clinical populations.
Contents:

PRISMA 2020 Checklist - Complete reporting checklist demonstrating adherence to PRISMA 2020 guidelines for systematic reviews and meta-analyses
Supplemental Table 1: Search Strategies - Detailed search strategies used across four major databases (PubMed, Web of Science, Embase, Cochrane Library) with complete Boolean search terms and filters
Supplemental Table 2: Basic Study Information - Comprehensive characteristics of all 28 included studies including participant demographics, intervention details, exercise parameters, and weekly MET calculations
Supplemental Table 3: Risk of Bias Assessment - Quality assessment results for all included studies using Joanna Briggs Institute critical appraisal tools for randomized controlled trials and quasi-experimental studies
Supplemental Table 4: Node Splitting Analysis - Statistical assessment of local inconsistency in the network meta-analysis using node-splitting methods to evaluate agreement between direct and indirect evidence
Supplemental Table 5: League Tables - Complete pairwise comparison results from network meta-analysis presented separately for healthy, obese, and patient populations with standardized mean differences and 95% confidence intervals

These materials provide transparency and reproducibility for the systematic review methodology and support the main findings regarding optimal exercise prescriptions for VEGF enhancement across different population groups. The study was pre-registered in PROSPERO (CRD42025643709) and followed established guidelines for network meta-analysis and dose-response analysis.