Dissection of Metabolic Reprogramming in Polycystic Kidney Disease Reveals Coordinated Rewiring of Bionergetic Pathways. Dissection of Metabolic Reprogramming in Polycystic Kidney Disease Reveals Coordinated Rewiring of Bionergetic Pathways

Analysis of genome-wide transcriptional changes in cystic kidneys in the hypomorphic Pkd1V/V mouse model at postnatal day 10. The hypothesis tested in the present study was that metabolism is reprogrammed in polycystic kidney disease (PKD) in this model. Results provide important information of metabolic changes that affect glycolysis, mitochondrial metabolism, and fatty acid synthesis in the pathogenesis of PKD. Overall design: Total RNA obtained from kidneys harvested from Pkd1V/V mouse mutants of 10 days of age compared to the wild-type littermates