Use of Fermented Red Clover Isoflavones in the Treatment of Overactive Bladder, focusing on vaginal and urine microbiota. human gut metagenome

This study focusing on overactive bladder disorder (OAB) symptoms was part of a three-month randomized, doubleblinded, placebo-controlled trial (ClinicalTrials.gov NCT05013593) investigating fermented redclover extract (RCE) as a treatment for postmenopausal women with bladder symptoms. The primary outcome of the trial was changes in the urinary and vaginal microbiota composition as well as clinical improvements. Four sample types were collected: Catheterized urine, midstream urine, vaginal swabs, and fecal samples