Bulk RNA-seq analysis in pulmonary endothelial cells between saline and LPS group, WT (Fgfr1loxp/loxp) and endothelial Fgfr1-conditional knock out mice (Fgfr1i?EC/i?EC mice).

Endothelial cells (ECs) serve as a semipermeable barrier and play a key role in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). It is well known that fibroblast growth factor receptor 1 (FGFR1) is a requirement for maintaining vascular integrity. However, how endothelial FGFR1 exerts its function remains obscure in ALI/ARDS. Here, we performed RNA-seq analysis to investigate transcriptional changes of ECs between saline and LPS group, WT (Fgfr1loxp/loxp) and endothelial Fgfr1-conditional knock out mice (Fgfr1i?EC/i?EC mice). Overall design: Comparative gene expression profiling analysis of RNA-seq data from saline and LPS group, WT (Fgfr1loxp/loxp) and endothelial Fgfr1-conditional knock out mice (Fgfr1i?EC/i?EC mice).