Data from: Large scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

Objective: To identify a plasma metabolomic biomarker signature for
migraine. Methods: Plasma samples from 8 Dutch cohorts (n = 10,153: 2,800
migraine patients and 7,353 controls) were profiled on a 1H-NMR-based
metabolomics platform, to quantify 146 individual metabolites (e.g.,
lipids, fatty acids, and lipoproteins) and 79 metabolite ratios.
Metabolite measures associated with migraine were obtained after
single-metabolite logistic regression combined with a random-effects
meta-analysis performed in a nonstratified and sex-stratified manner.
Next, a global test analysis was performed to identify sets of related
metabolites associated with migraine. The Holm procedure was applied to
control the family-wise error rate at 5% in single-metabolite and global
test analyses. Results: Decreases in the level of apolipoprotein A1 (β
−0.10; 95% confidence interval [CI] −0.16, −0.05; adjusted p = 0.029) and
free cholesterol to total lipid ratio present in small high-density
lipoprotein subspecies (HDL) (β −0.10; 95% CI −0.15, −0.05; adjusted p =
0.029) were associated with migraine status. In addition, only in male
participants, a decreased level of omega-3 fatty acids (β −0.24; 95% CI
−0.36, −0.12; adjusted p = 0.033) was associated with migraine. Global
test analysis further supported that HDL traits (but not other
lipoproteins) were associated with migraine status. Conclusions: Metabolic
profiling of plasma yielded alterations in HDL metabolism in migraine
patients and decreased omega-3 fatty acids only in male migraineurs.