Temporal Expression Profiling of Plasma Proteins in Type 1 Diabetes Progression

A longitudinal proteomic profiling of human plasma using TMT-10plex-based LC-MS/MS analysis was performed to track temporal proteomic changes of T1D patients (n = 11) across 9 serial time points, spanning the period of T1D natural progression, in comparison with those of the matching healthy controls (n = 10). Longitudinal expression profiles of >2000 human plasma proteins in T1D natural progression were presented in the current study.