Transcriptome analysis in the medial prefrontal cortex of mice exposed to multi-hit early adversity. Transcriptome analysis in the medial prefrontal cortex of mice exposed to multi-hit early adversity

We have employed whole genome microarray expression profiling to identify long-term gene expression changes associated with early adversity in male and female C3H/HeN mice Overall design: Multi-hit early adversity consisted in lipopolysaccharide injection at embryonic day 17 combined with maternal separation from post natal day 2 to 14. At adulthood (5.5 months) mice were euthanized and brains were collected for micropunch sampling within the medial prefrontal cortex