TFF1

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

三叶草家族成员以至少含有一个三叶草基序为特征，该基序由40个氨基酸组成的区域，其中包含三个保守的二硫键。它们是稳定分泌于胃肠道黏膜的蛋白质。其功能尚未明确，但可能具有保护黏膜免受损害、稳定黏液层以及影响上皮愈合的作用。该基因在胃黏膜中表达，因其在人肿瘤中的表达而受到研究。该基因及其两个其他相关三叶草家族成员基因位于21号染色体上的一个簇中。[由RefSeq提供，2008年7月]