RNA-sequencing of microglia, T cells and ILC2 from the brains of IL-33 treated aged (20-22mos) mice

ILC2 are potent producers of IL-5 and IL-13 and Th2 cytokines have been found to promote neurogenesis and cognitive functions. We report microglia, brain T cells and ILC2 have a range of differentially expressed genes in IL-33 treated aged mice. Brain ILC2 upregulated a range of neuroprotective genes. Overall design: We used Single-end 75 bp high throughput sequencing to detail the global programme of different gene expression between the microglia, T cells and ILC2 from the brains of IL-33 treated aged (20-22mos) mice.