Effects of Huatan Jiangzhuo Decoction and Poria cocos - Alismatis Rhizoma on gene expression in liver of rats with hyprelipidemia

Huatan Jiangzhuo Decoction, a traditional Chinese medicine composition, has been used to treat patients with hyperlipidemia (HLP). To investigate the therapeutic mechanism of Huatan Jiangzhuo decoction(HTJZD) and Poria cocos (PC) - Alismatis Rhizoma (AR) on gene expression in liver of rats with HLP, this study performed gene expression profiling analysis using data obtained from RNA-seq technology. It’s predicted that the potential role of regulating the expression of differentially expressed genes in the treatment of HLP by HTJZD and PC-AR separately.化痰降浊汤（Huatan Jiangzhuo Decoction）作为一种中药复方，已被用于治疗高脂血症（hyperlipidemia, HLP）患者。为探究化痰降浊汤（HTJZD）与茯苓（Poria cocos, PC）-泽泻（Alismatis Rhizoma, AR）对高脂血症大鼠肝脏基因表达的调控机制，本研究利用RNA测序（RNA-seq）技术获取的转录组数据开展基因表达谱分析，旨在阐明HTJZD与PC-AR分别通过调控差异表达基因的表达以治疗高脂血症的潜在作用机制。