Expression profiling explores pathways involved in pterygium progression

Pterygium is an ocular surface disease that can cause visual impairment if it progressively invades the cornea. Although many pieces of research showed that ultraviolet radiation triggers pterygium pathological progress, the underlying mechanism in pterygium remains indistinct. In this study, we used microarray to evaluate the changes of transcripts between primary pterygium and adjacent normal conjunctiva samples in China, hoping to find underlying pathways involved in pterygium progression. Two nasal primary pterygium samples and two adjacent normal conjunctiva samples were obtained from participants through pterygium excision surgery.