S. thermophilus BIMs used in the study and details on cleavage and EOP.

aThe other names are used in the text to help the reading.bBIM S4 was characterized elsewhere [12], [15] and used here as a control.cExperimentally proved cleavage site are symbolized with plain arrows, previously published [12], [15] cleavage sites are represented by clear arrows, whereas not experimentally determined cleavage sites are represented by grey arrows.dPAMs are 5′-NNAGAAW-3′ and 5′-NGGNG-3′ for CRISPR1 and CRISPR3 protospacers, respectively. Consensus nucleotides are underlined.eEOPs are the mean of at least three independent assays.