Genes critical for development and differentiation of dopaminergic neurons are downregulated in Parkinson’s disease. Genes critical for development and differentiation of dopaminergic neurons are downregulated in Parkinson’s disease

We performed transcriptome analysis using RNA sequencing on substantia nigra pars compacta (SNpc) from mice after acute and chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment and Parkinson’s disease (PD) patients. Overall design: Comparative gene expression profiling analysis of RNA-seq data for substantia nigra pars compacta from MPTP mice treated for 14 days and 24 hours (treated vs. control) and for human PD (PD patients vs. Control).