Quantitative 3D OPT and LSFM datasets of pancreata from mice with streptozotocin-induced diabetes: Sample data sets

Mouse models for streptozotocin (STZ) induced diabetes probably represent
the most widely used systems for preclinical diabetes research, owing to
the compound’s toxic effect on pancreatic ß-cells. However, a
comprehensive view of pancreatic β-cell mass distribution subject to STZ
administration is lacking. Previous assessments have largely relied on the
extrapolation of stereological sections, which provide limited 3D-spatial
and quantitative information. This data descriptor presents multiple ex
vivo tomographic optical image data sets of the full β-cell mass
distribution in mice subject to single high and multiple low doses of STZ
administration, and in glycaemia recovered mice. The data further include
information about structural features, such as individual islet β-cell
volumes, spatial coordinates, and shape as well as signal intensities for
both insulin and GLUT2. Together, they provide the most comprehensive
anatomical record of the effects of STZ administration on the islet of
Langerhans in mice. As such, this data descriptor may serve as reference
material to facilitate the planning, use and (re)interpretation of this
widely used disease model.