Additional file 1 of Plasma metabolites and risk of seven cancers: a two-sample Mendelian randomization study among European descendants

Additional file 1: Table S1. Information on genome-wide association studies (GWAS) of cancers among individuals of European ancestry. Table S2. Summary statistics of instrumental variables (IVs) for the 94 significant associations identified in primary Mendelian randomization (MR) analyses. Table S3. Significant associations identified in primary MR analyses using the inverse-variance weighted (IVW) method. Table S4. MR results based on instrumental variables (IVs) selected under a more stringent threshold (P < 5 × 10–8 & LD r2 < 0.001) for the 94 significant associations identified in primary analyses. Table S5. Summary statistics of instrumental variables (IVs) used for reverse Mendelian randomization (MR) analyses for the 94 significant associations identified in primary analyses. Table S6. Replication analyses results using an independent metabolite GWAS dataset for the 94 significant associations identified in primary analyses. Table S7. Twenty-one associations that remained significant in Multivariable MR (MVMR) analyses. Table S8. Seven metabolite-cancer pairs showing a nominally significant genetic correlation. Table S9. Colocalization analyses for the 94 significant associations identified in primary analyses.