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Crystal structure of PKA type I regulatory subunit bound with Rp-8-Br-cAMPS

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Protein Data Bank Japan2023-11-01 更新2026-03-21 收录
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Crystal structure of PKA type I regulatory subunit bound with Rp-8-Br-cAMPS Descriptor: (2R,4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-sulfide, ZINC ION, cAMP-dependent protein kinase type I-alpha regulatory subunit Authors: Swaminathan, K. Deposit date: 2010-11-15 Release date: 2010-12-01 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: Conformational selection highlights a new concept in allosteric inhibitor design To be Published
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2010-11-15
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