Processed Seurat objects from scRNA-seq data of the aging subventricular zone (SVZ) neurogenic niche with partial reprogramming

This repository contains the processed Seurat objects from the publication "Restoration of neuronal progenitors by partial reprogramming in the aged neurogenic niche" (https://doi.org/10.1038/s43587-024-00594-3).

Raw sequencing data is available at the Gene Expression Omnibus (GEO) under accession number GSE224438. Code used to process and analyze the data is available on GitHub (https://github.com/gitlucyxu/SVZreprogramming). 

These Seurat objects are filtered to high-quality singlets for samples included in the publication. Descriptions and notable metadata:

svz_iOSKM_cohort1_toshare.rds - SVZ after whole-body partial reprogramming, cohort 1

Celltype - cell type annotation

Treatment - condition

untr: old control

2Dox0: old+OSKM

hash.ID - mouse ID (biological replicate)

svz_iOSKM_cohort2_toshare.rds - SVZ after whole-body partial reprogramming, cohort 2

Celltype - cell type annotation

Age_Treatment - condition

young_untr: young control

old_untr: old control

old_2Dox0: old+OSKM

hash.ID - mouse ID (biological replicate)

svz_ciOSKM_toshare.rds - SVZ after SVZ-targeted partial reprogramming

Celltype - cell type annotation

Age_Treatment - condition

young_untr: young control

old_untr: old control

old_Dox: old+OSKM(SVZ)

MULTI_classification_rescued - mouse ID (biological replicate)

Updated 2024/07/01 (v2): replaced a corrupted file.