Mutations in the human X-linked doublecortin gene (DCX) cause major neocortical disorganization associated with severe intellectual disability and intractable epilepsy. Although Dcx knockout (KO) mice
Neurodevelopmental insults leading to malformations of cortical development (MCD) are a common cause of psychiatric disorders, learning impairments and epilepsy. In the methylazoxymethanol (MAM) model
Purpose: Understanding the role of RBX2 during hippocampla development, pyramidal neuron migration and dendritogenesis. Comparison of mRNA profiles from control (Rbx2 flox/flox) (Ctrl) and Rbx2 mutan