Multi-omics analysis of dynamic dose-response in macrophages recapitulates multi-walled carbon nanotube -induced lung fibrosis [expression]

Multi-omics approach to characterize the dynamic dose-dependent (DDD) molecular alterations in a model of human macrophages was used to highlight key-genes altered due to rCNT exposure. Results emphasize short and long term changes in gene regulation, that further suggest fibrotic responses, previously reported in in vivo animal model. The gene expression profiles of THP-1 macrophages exposed to three concentrations (5, 10 or 20 µg/mL) of rigid multi-walled carbon and untreated controls were profiled at 24, 48 and 72 hours. Each group was performed as triplicates.