miR-101a-3p impairs synaptic plasticity and contributes to synucleinopathy. miR-101a-3p impairs synaptic plasticity and contributes to synucleinopathy

We performed small RNA-Sequencing of midbrain from 6-month-old transgenic (Tg) mice expressing A30P mutant aSyn, followed by comparative expression analysis, and found that several deregulated biological processes were linked with the synapse. Overall design: Examination of midbrain miRNAome in 6 month old mice wild type (WT) and A30P mutant alpha-synuclein mice