Amino acid sequences of the three predicted P. falciparum CSP CD8+ T-cell epitopes (K, M and Y) based on binding to major human HLA haplotypes.

Shown are comparisons to the known sequence in the 3D7 strain of P. falciparum CSP (used for human volunteer challenge trials) and to the Wellcome Strain of P. falciparum CSP sequence expressed in the Tg-Pb/PfCSP sporozoites (used in these mouse studies). Underlined residues in Wellcome strain highlight the differences from the 3D7 strain.