BIOGRID CURATED DATA FOR VAC14 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for VAC14 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Enzyme regulator; involved in synthesis of phosphatidylinositol 3,5-bisphosphate, in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; binds negative (Fig4p) and positive (Fab1p) regulators of PtdIns(3,5)P(2) to control endolysosome function; similar to mammalian Vac14p

蛋白质-蛋白质、遗传以及化学相互作用数据集，针对酵母菌（Saccharomyces cerevisiae S288c）中的VAC14（酶调节因子）由BioGRID（https://thebiogrid.org）整理；定义：参与磷脂酰肌醇3,5-二磷酸的合成，在控制某些蛋白质通过MVB（多泡体）转运至液泡腔内以及维持液泡大小和酸度方面发挥作用；与PtdIns(3,5)P(2)的负调节因子（如Fig4p）和正调节因子（如Fab1p）结合，以调控内体溶酶体功能；与哺乳动物中的Vac14p相似。