Synthesis of Substituted 2,3-Benzodiazepines
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https://figshare.com/articles/dataset/Synthesis_of_Substituted_2_3-Benzodiazepines/4019622
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资源简介：
A new,
four-step synthetic route for substituted 2,3-benzodiazepines 1, starting from aldehyde 4, was developed with
excellent overall yields. This route included the 1,2-addition of
various aromatic Grignard reagents to 4, PCC oxidation,
and aerobic Wacker-type oxidation of the olefinic group of 6, followed by condensation of the resulting 1,5-dicarbonyl 7 with N2H4. Isoquinolones 9 were obtained when an aldehyde group was used instead of a ketone.
The key structures were confirmed by X-ray single-crystal diffraction
analysis.
创建时间：
2016-10-17
