Differentially-expressed genes in blood in response to lipopolysaccharide in three rodent species

Infection tolerance in rodents was examined by injecting single-dose
lipopolysaccharide (LPS) to induce inflammation in Peromyscus
leucopus (LL stock), the white-footed deermouse also reservoir
for Lyme disease and Mus musculus (outbred CD-1 breed),
the house mouse, and Rattus norvegicus, the brown rat (Fischer
strain). Reaction to LPS was analyzed in the blood of challenged rodents
and compared to control animals. As natural reservoirs of zoonoses
deermice show significant anti-inflammatory response as described in
"An Infection-Tolerant Mammalian Reservoir for Several Zoonotic
Agents Broadly Counters the Inflammatory Effects of Endotoxin"
(https://doi.org/10.1128/mBio.00588-21). The project and the description
of the samples are described under the following NCBI BioProjects:
PRJNA975149
(https://www.ncbi.nlm.nih.gov/bioproject/PRJNA975149) for mouse
and deermouse and PRJNA973677
(https://www.ncbi.nlm.nih.gov/bioproject/PRJNA973677). This project is a
follow-up project focusing on the transcriptomic analysis of the whole
blood bulk RNA-seq and further analysis of differentially expressed genes
(DEG) between the treatment arm and controls. Complete fold change and
false discovery rate for all three rodent species used for the current
Dryad set are previously published (https://doi.org/10.7280/D1470Z). Here
we report that deermice tolerance to infection is partly due to lower
expression of interferon-gamma in comparison to mice and rats.