ARRB1 inhibits the progression of non-alcoholic steatohepatitis by promoting the intracellular processing of GDF15. ARRB1 inhibits the progression of non-alcoholic steatohepatitis by promoting the intracellular processing of GDF15

ARRB1 is a vital regulator in the development of NASH via facilitating GDF15 translocate to Golgi apparatus and maturation. ARRB1 is a potential therapeutic target for the treatment of NASH. Overall design: Hepatocytes mRNA profiles of ARRB1-/- and WT mice fed with HFD for 26 weeks were generated by deep sequencing, in triplicate.