Amplicon sequencing Raw sequence reads

In this study, we collected fecal samples from OSA patients and healthy controls, and systematically analyzed the structural and functional differences of the intestinal flora between the two groups using 16S rRNA gene sequencing technology. The study covers the analysis of flora diversity (Alpha/Beta diversity), changes in abundance of key genera, and prediction of functional pathways, and explores the mechanism of flora-host interactions in combination with clinical indicators (e.g., AHI index, oxygen saturation, BMI, etc.). OSA-specific biomarkers were mined through a multidimensional statistical approach to provide microbiomic evidence for disease mechanism exploration.