Associations with clinical outcomes.

Pearson’s correlations comparing each of the arrays and pathways tested were used to quantify the overall contribution of a given pathway within an individual patient. These scores were then compared against clinically relevant factors including age, sex, modified Rodnan skin score (MRSS), biopsy site, and disease duration to assess the predictive value of each pathway for disease outcomes. Early disease was defined as disease ≤ 2 years after first non-Raynaud’s phenomenon symptoms. Comparisons were performed with clinically diffuse patients only, using a single array per patient for each time point collected. Comparisons of biopsy site were limited to clinically diffuse patients which provided paired lesional and non-lesional biopsies at a given time point; n denotes the number of patients included in each analysis. Continuous variables were compared using Pearson’s correlation; categorical variables were analyzed by ANOVA.
* denotes p < 0.05.
Associations with clinical outcomes.