Multi-omics reveals cholesterol-driven macrophage metabolic reprogramming and inflammation in chronic obstructive pulmonary disease

Cholesterol accumulation contributes to COPD pathogenesis by inducing metabolic reprogramming and proinflammatory signaling pathway in macrophages, which provides novel insights into the prevention and treatment of this disease clinically. Multi-omics including metabolomics, RNA_Suq and scRNA_Suq were integrated for disclosing the underlying mechanisms of COPD.