Reaction of Silyldihalomethyllithiums with Nitriles: Formation of α-Keto Acylsilanes via Azirines and 1,3-Rearrangement of Silyl Group from C to N
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https://figshare.com/articles/dataset/Reaction_of_Silyldihalomethyllithiums_with_Nitriles_Formation_of_Keto_Acylsilanes_via_Azirines_and_1_3_Rearrangement_of_Silyl_Group_from_C_to_N/3331585
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资源简介：
A synthesis of α-keto acylsilanes, where 2-bromo-2H-azirine participates as a key intermediate, is reported. The reaction of silyldibromomethyllithium with aryl nitriles provides α-keto acylsilanes in good yields. Interestingly, silyldichloromethyllithium induces aza-1,3-Brook rearrangement of the silyl group in th reaction with nitriles. The rearrangement enables a three-component coupling reaction in a one-pot operation.
创建时间：
2004-07-21
