Antibody responses to varying doses of rhGAA in null mutation (n = 6) or P545L mutant mice (n = 5).
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A) Anti-rhGAA IgG1 in 1 mg/kg rhGAA injected GAA-/- 129SVE mice tested weekly B) Anti-rhGAA IgG1 in 5 mg/kg rhGAA injected GAA-/- 129SVE mice C) Anti-rhGAA IgG1 in 20 mg/kg rhGAA injected GAA-/- 129SVE mice D) Anti-rhGAA IgG1 response in 20 mg/kg rhGAA injected P545L mice E) Anti-rhGAA IgG2a in 1 mg/kg rhGAA injected GAA-/- 129SVE mice F) Anti-rhGAA IgG2a in 5 mg/kg rhGAA injected GAA-/- 129SVE mice G) Anti-rhGAA IgG2a in 20 mg/kg rhGAA injected GAA-/- 129SVE mice H) Anti-rhGAA IgG2a in 20 mg/kg rhGAA injected P545L mice. Arrows indicate fold decrease over corresponding 20 mg/kg cohort time point. p<0.05 *, p<0.005 **, p<0.0005 ***, ns = not significant.
创建时间：
2016-02-23
