Upper/lower respiratory tract microbiome changes patients with COPD

Chronic obstructive pulmonary disease is a common disease of respiratory system threatening the health of people, and respiratory tract infection is one of the important reasons due to acute exacerbation in COPD patients. However, the traditional research methods cannot fully reveal the bacterial diversity of the respiratory tract. At present, there are a few literatures on the composition and changes of respiratory tract bacterial populations with the technology of metagenomics which are related to the occurrence and development of COPD. In addition some questions consistently exist as following: It is few longitudinal study of the change of bacterial populations in the different course of COPD. whether the constitution of respiratory bacterial population changes or not, there are contradictions between different research results. It is clear that the bacterial diversity of other respiratory diseases is related with the climate and race, whereas it keep vague whether it can affect the composition of respiratory bacteria in COPD. Therefore, to analyze the changes of microbiome in respiratory tract of patients with different course of COPD between different regions and ethnic groups in Yunnan province, investigate the microenvironment of respiratory and the markers related with the exacerbation of COPD, and clarify the effect of respiratory tract bacterial population structure on the course of COPD. That will establish a important theoretical basis in our study, for the guidance of taking targeted prevention and treatment,reduce the number of patients with acute exacerbation of hospitalization, shorten the course of the disease.