Iridium-Catalyzed Allylation of Chiral β‑Stereogenic Alcohols: Bypassing Discrete Formation of Epimerizable Aldehydes
收藏NIAID Data Ecosystem2026-03-07 收录
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The cyclometalated π-allyliridium 3,4-dinitro-C,O-benzoate complex modified by (R)- or (S)-Cl,MeO-BIPHEP promotes the transfer hydrogenative coupling of allyl acetate to β-stereogenic alcohols with good to excellent levels of catalyst-directed diastereoselectivity to furnish homoallylic alcohols. Remote electronic effects of the C,O-benzoate of the catalyst play a critical role in suppressing epimerization of the transient α-stereogenic aldehyde.
创建时间：
2016-02-20
