Prevalence of Impaired Fasting Glucose and Impaired Glucose Tolerance in the First-Degree Relatives of Patients with Type 2 Diabetes Mellitus

AbstractBackground and Objectives: Prediabetes is characterized by impaired fasting glucose (IFG)and impaired glucose tolerance (IGT). It poses a higher risk of progressing to diabetes,particularly in first-degree relatives (FDRs) of individuals with Type 2 diabetes. This studyaimed to assess the prevalence of IFG and IGT in FDRs of individuals diagnosed with Type 2diabetes mellitus (T2DM).Materials & Methods: 300 participants (201 males and 99 females) who were FDRs ofpatients with T2DM, aged 18 years and above, were selected from rural area of centralMadhya Pradesh. Fasting blood sugar (FBS) and 2-hour postglucose blood sugar (PG2BS)levels were measured using a fully automated analyzer employing the enzymaticcolorimetric.Results: The study revealed that prevalence of IFG among FDRs of individuals with T2DMwas approximately 15.1%. Additionally, 12% of the participants were newly diagnosed withdiabetes based on their FBS levels. Notably, only 14% of the subjects exhibited impairedPG2BS levels, and the prevalence of diabetes determined by this method closely aligned withthe FBS method.Conclusion: The prevalence of diabetes is rapidly increasing, even in rural India. There isurgent need for preventive measures and interventions to curb the escalating rates andpromote better health outcomes in these communities.