Temporal proteomic changes in hippocampus and cerebral cortex of mice carrying creatine transporter deficiency patient-derived mutation

Mutations in SLC6A8, which encodes the creatine transporter (CRT), cause creatine transporter deficiency (CTD), an X-linked genetic disorder characterized by pediatric intellectual disability due to brain creatine deficiency. In this study, we investigated the temporal proteomic changes in hippocampus and cerebral cortex of mice carrying creatine transporter deficiency patient-derived mutation.