Genome-wide maps of Lamin A-LADs binding affinity in control and LMNA R527C mutant MSCs

To determine if LMNA R527C mutation affect the arrangement and function of LADs, we performed Lamin A ChIP-seq in wild type and mutant MSCs. Reads of Lamin A ChIP-seq in LADs were decreased in mutant cells compared with wild type. These data suggested that the binding affinity of Lamin A to LADs was reduced after R527C mutation Overall design: To determine if R527C mutation affects the arrangement and function of LADs, we performed Lamin A ChIP-seq in control and LMNA R527C mutant MSCs. Examination of Lamin A-LADs binding affinity in control and LMNA R527C mutant MSCs.