Microbiome and metabolome features of patients with diarrhea-type irritable bowel syndrome complicated with anxious-depressive states

Patients with diarrhea-type irritable bowel syndrome (IBS-D) often have symptoms of anxiety and depression. Several studies suggest that IBS-D patients may suffer from structural disturbances in the gut flora associated with psychiatric symptoms such as anxiety and depression. It has also been found in clinic that some IBS-D patients can benefit from certain probiotic treatments. In this study, 16SrDNA sequencing and non-targeted metabolomics analysis were used to explore the differential microorganisms and metabolites related to the physical and psychological symptoms of IBS-D patients, which provided clues for intestinal targeted therapy in IBS-D patients.

腹泻型肠易激综合征（IBS-D）患者常伴随焦虑与抑郁症状。多项研究表明，IBS-D患者可能存在与焦虑、抑郁等精神症状相关的肠道菌群结构紊乱。临床中还发现，部分IBS-D患者可通过特定益生菌治疗获益。本研究采用16S rDNA测序与非靶向代谢组学分析，探究与IBS-D患者身心症状相关的差异微生物与代谢物，为IBS-D患者的肠道靶向治疗提供了研究线索。

搜集汇总

背景与挑战

背景概述

该数据集包含62例腹泻型肠易激综合征伴随焦虑抑郁状态患者的粪便样本测序数据，使用Illumina MiSeq平台生成，每个样本的测序量在24.3M到38.1M碱基之间。数据可用于研究肠道微生物组和代谢组特征与IBS-D及精神状态的关联。