High Throughput Chromosome Conformation Capture identifies differential genome organization in virulent and avirulent strains of Mycobacterium tuberculosis. High Throughput Chromosome Conformation Capture identifies differential genome organization in virulent and avirulent strains of Mycobacterium tuberculosis

In order to understand the three-dimensional genome organization in M. tuberculosis, in this study we have used exponentially growing mycobacterial culture. We performed Hi-C on both virulent and attenuated strain of M. tuberculosis and analyzed data by using Hi-C explorer tools Overall design: Comparative chromosome oganization in Mycobacterium tuberculosis strain H37Rv and H37Ra using Hi-C