Chemotherapy-driven intestinal dysbiosis and microbial indole-3-propionic acid rewire bone marrow myelopoiesis to promote anti-metastatic immunity

We investigated how microbial derived product influence myeloid cell differentiation in vitro. Overall design: To assess the effect of indole-3-propionic acid (IPA) on MDSC generation, we exposed bone marrow cells to MDSC-inducing media in the presence of vehicle, 10uM IPA or 50uM IPA.