Atrial myocytes-derived exosomal microRNA contributes to atrial fibrosis in atrial fibrillation

We demonstrate that atrial myocytes-derived exosomal miR-210-3p promoted the proliferation and collagen synthesis via inhibiting GPD1L in atrial fibroblasts. Preventing pathological crosstalk between atrial myocytes and fibroblasts may be as a novel target to improve atrial fibrosis in AF.本研究证实，心房肌细胞来源的外泌体微小RNA-210-3p（miR-210-3p）通过抑制心房成纤维细胞中的甘油磷酸脱氢酶1样蛋白（GPD1L），促进心房成纤维细胞的增殖与胶原蛋白合成。阻断心房肌细胞与成纤维细胞间的病理性串扰，或可作为改善心房颤动（Atrial Fibrillation, AF）相关心房纤维化的全新治疗靶点。