The Cancer Genome Atlas Liver Hepatocellular Carcinoma Collection

<p>The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) data collection is part of a larger effort to build a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to subjects from <a href="http://cancergenome.nih.gov/">The Cancer Genome Atlas (TCGA)</a>. Clinical, genetic, and pathological data resides in the <a href="https://portal.gdc.cancer.gov/exploration?filters=%7B%22op%22%3A%22and%22%2C%22content%22%3A%5B%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.program.name%22%2C%22value%22%3A%5B%22TCGA%22%5D%7D%7D%2C%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.project_id%22%2C%22value%22%3A%5B%22TCGA-LIHC%22%5D%7D%7D%5D%7D">Genomic Data Commons (GDC) Data Portal</a> while the radiological data is stored on The Cancer Imaging Archive (TCIA). </p><p>Matched TCGA patient identifiers allow researchers to explore the TCGA/TCIA databases for correlations between tissue genotype, radiological phenotype and patient outcomes.  Tissues for TCGA were collected from many sites all over the world in order to reach their accrual targets, usually around 500 specimens per cancer type.  For this reason the image data sets are also extremely heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols.  In most cases the images were acquired as part of routine care and not as part of a controlled research study or clinical trial. </p><h3>CIP TCGA Radiology Initiative</h3><p>Imaging Source Site (ISS) Groups are being populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, ISS groups are given the opportunity to publish a marker paper for a given cancer type per the guidelines in the table above. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource.  Learn more about the <a href="https://wiki.cancerimagingarchive.net/display/Public/CIP+TCGA+Radiology+Initiative">CIP TCGA Radiology Initiative</a>.</p>

肿瘤基因组图谱（The Cancer Genome Atlas，TCGA）肝脏肝细胞癌（Liver Hepatocellular Carcinoma，LIHC）数据集系构建一个致力于将癌症表型与基因型相连接的研究共同体的一部分。该共同体通过提供与癌症基因组图谱（TCGA）受试者相匹配的临床图像来实现这一目标。临床、遗传和病理数据存放在基因组数据共享平台（Genomic Data Commons，GDC）数据门户中，而影像学数据则存储在癌症影像存档（The Cancer Imaging Archive，TCIA）中。匹配的TCGA患者标识符使研究人员能够探索TCGA/TCIA数据库，以研究组织基因型、影像学表型和患者预后之间的相关性。TCGA所用的组织样本来自全球多个地点，旨在达到约500个样本的积累目标，因此图像数据集在扫描器模式、制造商和采集协议方面也极为异质。在大多数情况下，图像的获取是作为常规护理的一部分，而不是作为受控的研究研究或临床试验的一部分。影像源站点（Imaging Source Site，ISS）组正在由向存档提供特定癌症类型影像数据的机构参与者组建和监管。这些ISS组仿照TCGA分析组，有机会根据上表中的指南为特定癌症类型发表标记论文。这一机会将促进构建这些多机构数据集的参与度，因为它们成为开放的社区资源。更多关于癌症影像存档计划（CIP TCGA Radiology Initiative）的信息，请参阅相关链接。

搜集汇总

背景与挑战

背景概述

TCGA-LIHC数据集是TCGA项目的一部分，专注于肝细胞癌的临床图像与基因型关联研究，包含临床、遗传、病理和放射学数据，数据来源广泛且具有高度异质性。该数据集支持研究者探索组织基因型、放射学表型与患者结果之间的相关性，并通过CIP TCGA Radiology Initiative促进多机构合作和开放资源共享。