Data from: Alkaline phosphatase, lactic dehidrogenase, inflammatory variables and apparent diffusion coefficients from MRI for prediction of chemotherapy response in osteosarcoma

Background. This present study aimed to assess if clinical, laboratory and
MRI were an accurate benchmark in assessing the effectiveness of
neoadjuvant chemotherapy in osteosarcoma patients. Methods. This was an
observational analytic study with a cross-sectional design. Research
subjects were selected using the total sampling method from osteosarcoma
patients who underwent neoadjuvant chemotherapy during the period between
January 2017– July 2019. Results.Of the 58 patients included in this
study, 38 were male and 20 were female aged 5 - 67 years
(mean,16-year-old. 37(63.8%) patients underwent neoadjuvant chemotherapy
with CAI regimens and 13 (36.2%) with CA. The tumors were classified as
stage IIB in 43 (74.1%) patients and stage III in15 (25.9%) patients.
After undergoing neoadjuvant chemotherapy, 4 patients had poor MSTS, 30
patients had fair MSTS, 17  and 7 patients had good and excellent
MSTS score, respectively. Spearman’s test revealed no correlation between
tumor necrosis after neoadjuvant chemotherapy with a reduction in tumor
size and MSTS score. Wilcoxon test showed significant differences between
ALP, ESR, and NLR before and after neoadjuvant chemotherapy in the
poor-response group. We found no significant difference between LDH and
LMR before and after neoadjuvant chemotherapy in the good-response group.
We had 9 patients for ADC value only. No significant statistical
differences were found in tumor volumes after chemotherapy in both groups.
Conclusion. We demonstrated that ALP level after neoadjuvant chemotherapy
was markedly decreased, and was statistically significant in the
poor-response group. We also demonstrated that LDH value before
neoadjuvant chemotherapy had a strong correlation with degree of necrosis
and could be used as a predictive indicator. NLR and LMR cannot be
independent prognostic factors. MRI plays an important role in evaluating
tumor volumes and preoperative radiological changes, using DWI and water
diffusion to predict histological necrosis.